A papal charter from 1261 mentions the "Villa Daslar" – present-day Daxlanden. A resettlement of the village in 1651 was unavoidable after a dam burst, as its location as a customs post on the Rhine had generated substantial revenues since the Middle Ages. Gold was also panned in Goldgrund until the 18th century. After the Rhine correction by Tulla and the ongoing disputes with Palatinate communities, the function as a shipping and customs station finally shifted to the right bank of the Rhine. After the Rhine port opened in 1901, the former fishing and farming village increasingly became a working-class village. In 1910, Daxlanden was incorporated into Karlsruhe. With its idyllic and harmonious greenery and scenic surroundings, the district is more like a village than a district of Karlsruhe. The Albsiedlung and Rheinstrandsiedlung complement this historic townscape.

Since there is hardly any through traffic, Daxlanden is relatively quiet and twenty minutes from the center of Karlsruhe. The operations at the Rhine port and their emissions are the only disturbing aspects of this place. With over 30 clubs, old half-timbered houses and the almost 300-year-old St. Valentniskirche, Daxlanden is worth seeing and has a diverse community life.