Grötzingen is a district on the eastern edge of Karlsruhe. In 1974 Grötzingen was incorporated into the city of Karlsruhe. As of 2014, the district has 9,168 inhabitants. Grötzingen was first mentioned in 985 under the name "Grezingen", which was derived from the name of the clan elder "Grezzo". Durlach was founded in the Grötzinger district in the twelfth century. The Durlacher Turmberg served as a mansion for the Grötzinger Count in the thirteenth century. The Grötzinger painters' colony was founded in the 19th century; the most famous members were: Friedrich Kallmorgen, Magarethe Hormnuth-Kallmorgen, Gustav Kampmann, Karl Biese, Franz Hein, Jenny Fikentscher, Otto Fikentscher and Oskar Hagemann. The group finally disbanded in 1903, and many Grötzingen cultural workers still see themselves in this tradition today. In 1888, the year the painters' colony was founded, Bertha Benz drove the route from Mannheim via Grötzingen to Pforzheim.

Since 2008, the Bertha Benz Memorial Route, which runs through Grötzingen, has been commemorating this first long-distance automobile journey in history. In March 1973, a village decision was made about Grötzingen joining the municipality of Pfinztal. The vote showed that 63% were in favor of joining and 26% were against. Since 44.58% of those who took part in the election were in favor of joining, Grötzingen was not incorporated. A year later, Grötzingen was incorporated into Karlsruhe. Grötzingen has a train station on the Karlsruhe - Mühlacker railway line, as well as the Kraichgaubahn to Heilbronn. Stadtbahn Karlsruhe trams currently stop at the station. Regional trains used to stop at the station. The platform used has now been abandoned and is weathering over time. The Grötzinger train station is also served by bus lines 21 and 22, which go to Durlacher Turmberg or neighboring towns, among other places.